Pearson won the 200 meters in a time of 23.78, easily beating back the competition. She won the 100 meters for the first time in the league championship meet with a time of 11.61.
The Sheffield, England native scored 20 of the Bulldogs' 38 points in the meet.
"Natalie was brilliant today," declared Asheville coach Jesse Norman. "She was simply outstanding. It was very exciting to watch her run."
Pearson was also named to the Big South All-Academic team at the conclusion of the meet.
The Bulldogs also had some other good performances on Saturday. Sarah Gentry took third in the 800 meters at 2:15.12.
Emma Bussard followed up her second-place finish in the Steeplechase with a sixth-place finish in the 1500 meters with a time of 18:00.47. She edged out Kaylan Peck of High Point.
Ashlei Clodfelter just missed getting Asheville some points in the javelin as she came in ninth with a toss of 35.06 meters. Meredith Foster was 10th in the high jump at 1.55 meters. The Bulldogs had two runners in the finals of the 1500 meters. Alyska Kalmeijer took 10th (5:02) and Rachel Carson finished 11th (5:07).
On the men's side, freshman Milan Ristic continued his good work in his rookie season as he took third in the 110 Hurdles with a time of 14.48.
Sam Maynard had a fifth-place finish in the 800 at 1:54.
Simon Haake came close to earning points for the Bulldogs in the shot put (14.16 meters) and hammer throw (48.30 meters) as he came in ninth place in both events.
Haake, who finished third in the javelin, was named to the Big South All-Academic team.